ABSTRACT
The aim of present study was to explore the impact of Atorvastatin (ATR) Sulfobutylether beta-cyclodextrin complex(ATR-SBE-β-CD) on ATR dissolution behavior. Various batches of inclusion complexes were formulated usingvarious drug: polymer ratios (1:1, 1:3, and 1:5); using β-CD and SBE-β-CD and using two methods (freeze dryingand kneading method). Phase solubility studies were carried out of all the complexes and ratio 1:5 (ATR-SBE-β-CD)prepared by freeze-drying yield maximum solubility enhancement (30-fold in comparison to pure drug). Fouriertransformation infrared spectroscopy, Powder X-ray diffraction, Scanning electron microscopy (SEM), Differentialscanning calorimetry (DSC) studies was also carried out. FTIR studies showed no drug polymer interaction. DSCand SEM studies suggested incorporation of drug into inclusion complexes of cyclodextrin. Solid dispersion viaFreeze drying technique using SBE-β-CD (1:3 ratio of drug to polymer) produces better dissolution characteristics incomparison to kneading method. The results revealed superiority of SBE-β-CD over β-CD for solubility enhancementof poorly soluble drugs (owing to amorphous nature and more stable form of SBE β-CD). No significant drug losswas observed in solid dispersion batch (as per results of drug content analysis) during storage for 3 months underaccelerated conditions. Further in vivo pharmacodynamics studies of selected batch were carried out by inducingobesity in rats by feeding them with a high-fat diet. Group I (normal control group) received normal chow diet andgroup II, group III, group IV (High fat diet group, optimized formulation group and disease control group) receivedHFD for 1 month and were further evaluated for BMI, Blood glucose, lipid profile, liver profile, and histopathologicalexamination. The results so obtained depicted that optimized formulation of Atorvastatin (10 mg/kg, p.o.) showedbetter results in comparison to pure Atorvastatin Calcium (10 mg/kg, p.o.).
ABSTRACT
The main use of surgical sutures is to assist closure and healing of trauma-induced as well as surgical wounds. Thisis done by upholding wound tissues together in order to facilitate the healing process. A huge variety of suturesare available for the medical purposes, e.g., bio active sutures, knot-less sutures, electronic sutures, drug-elutingsutures, anti-microbial sutures, and stem cells containing sutures. Sutures increase the capabilities to improve tissueapproximation and wound healing. Sutures with drug eluting property are the advanced type of sutures being used forsurgical purpose via delivery of drug to the specified area. Various new strategies develop the effectiveness of suturesto be used as physical entity to get better biologically active component which enables the delivery of various desirabledrugs and cells to the affected site. Ideal modified sutures should not only retain its mechanical integrity during thehealing process, but should also deliver the drugs loaded in it, in a controlled manner. These nano-structured fibers,produced by electrospinning and electrospraying techniques, offer tuneable release kinetics applicable to diversebiomedical applications. Drug eluting sutures lead to reduced surgical site infections, accelerated wound healing,reduced post-operative complications, and the most important thing is it reduces the need for supplement drugs. It willbe the biggest achievement if we get the desired concentration and effect of the loaded drug in these sutures withoutaffecting its mechanical properties. This can be achieved by enhancing/modifying the control release approaches. Thecurrent review gives updated information on recent advances in drug eluting sutures.